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四君子汤抗自由基损伤的研究
Pharmacological Research of Si Juln Zi Tang on Antagonising Free Radical Injury
【摘要】 本文观察了四君子汤对臭氧(O3)造成的自由基损伤的实验性衰老模型的影响。结果显示:四君子汤能明显改善衰老模型出现的体力下降、御寒能力和对缺氧的耐受力降低,并降低脂质过氧化物(LPO)含量和脑B型单胺氧化酶(MAO-B)活力,升高血清超氧化物歧化酶(SOD)活力。证明四君子汤具有抗自由基损伤的功能,能延缓衰老。
【Abstract】 This article deals with free radical injury model induced by ozone and the anti-aging effect of Si Juin Zi Tang. The results showed that, in model group, physical st~ renth, the ability of cold-resistant and hypoxia-resistant were reduced; the lipid peroxides (LPO) content in plasma, brain, liver and the MAO-B activity of brain were increased; the SOD activity of serum was decreosed as compared witn Model group. these changes were the same with that in old age mice. Si Juin Zi Tang ( 6 , 12g/kg po) could emeliorate these changes induced by ozone. It was shown that Si Juin Zi Tang possessed the effect of antagonising free radical injury.
【Key words】 Si Juin Zi Tang; ozone; antagonising free radical injury; lipid perox; ides; MAO-B; SOD;
- 【文献出处】 中药药理与临床 ,Pharmacology and Clinics of Chinese Materia Medica , 编辑部邮箱 ,1992年04期
- 【被引频次】25
- 【下载频次】82