【摘要】 实验观察到束缚可使大鼠产生严重的应激,表现为血浆促肾上腺皮质激素（ACTH）上升（P<0.001）,甲状腺素（T₄）和三碘甲状腺素（T₃）下降（P<0.05）。同样条件下给大鼠腹腔注射促甲状腺激素释放激素（TRH,25μg/kg体重）,大鼠血浆中的ACTH同束缚组相比明显下降（P<0.001）;T₃、胰岛素（INS）、血糖（Glu）同束缚组相比明显回升（P<0.05）,结果提示,外周的TRH参与束缚条件下ACTH的调节。更多还原

【Abstract】 Strong stress in response to restraint was observed in rats. In these rats, plasma ACTH increased significantly （P<0.001） while T₃ and T₄ decreased （P<0.05）. After the rats were injected intraperitoneally with TRH,the plasma ACTH increase was obviously attenuated （P<0.001）, while T₃ INS and GLU increased （P<0.05） as compared with control rats. The results indicate that peripheral TRH participates in ACTH regulation daring restraint stress.更多还原