【摘要】 用0.15μg/mlPHA 诱导 T 细胞活化作模型,发现 TⅡ（5μg/ml）和 Bt₂cAMP（500μm）均能抑制 T 细胞从 Go 相进入 G₁a 相和从 G₁a 进入 G₁b 相,并抑制活化抗原 Tac、Ia、T（?） 和4F2的表达.TⅡ和Bt₂cAMP 还抑制活化 B 细胞在外源性 IL—2诱导下进入 S 相和 G₂/M 相.另外,T Ⅱ和 Bt₂cAMP 还抑制 T细胞在1.5μg/mlPHA 诱导下产生 IL-2。TⅡ和 Bt₂cAMP 的上述作用十分相似.有趣的是,TⅡ和 T细胞一起培养30小时,T 细胞中 cAMP 量明显增多。cAMP 增加程度与 TⅡ剂量正相关。上述结果提示,TⅡ对 T细胞增殖的抑制作用至少部分经由 cAMP.更多还原

【Abstract】 It has been observed in human T cells activted with 0.15μg/ml of PHA that both T Ⅱ（5μg/ml）and Bt₂cAMP（500μM）inhibites the entrance of T cells from GO into G_1aphase and from G_1ainto G_1bphase,and inhibites the expression of activation antigens Tac,Ia T₉ and 4F2.Both T Ⅱ and BT₂cAMP also suppress the entrance of activated T cells into S and G₂/M phase in response to exogenous IL—2,and suppress IL—2 production of T cells stimulatde with 1.5μg/ml of PHA.The suppressive effect of T Ⅱ and Bt₂cAMP is quite similar.Interestingly,T■can induce cAMP increase in T cells in a dose—dependent manner.The data suggests that the suppressive effect of T■on T cell proliferation might be（at least partially）mediatde by cAMP.更多还原