【摘要】 本文将22只家兔随机分为三组。喂饲胆固醇诱发高脂血症。实验组给予疏水性表面活性剂Soluchorol,探讨其对高脂血症及动脉硬化的预防作用。结果表明,实验组血清总胆固醇及低密度脂蛋白均明显低于高脂组(P<0.01)。血清过氧化脂质亦低于高脂组(P<0.05)。二组主动脉斑块面积及厚度的对比分析均有显著性差异。提示疏水性表面活性剂具有一定的降血脂及预防动脉硬化的作用。但对Soluchorol的合成过程及其在机体内的代谢过程,使用剂量及毒性,试验等方面尚需进一步研究。更多还原

【Abstract】 Twenty-two male rabbits were randomly divided into three groups, and fed with a control diet (group A), an atherogenic diet (group B and C), and diet of group C were supplemented with 0.5% hydrophobic surfactant-Soluchorol. The animals in group C showed signifcantly lower levels of cholesterol and LDL in serum than those in group B. The atherosclerotic lesions of the aorta from the group C were also less than that from group B. The results demonstrate hydrophobic surfactant has the reduting effect of cholesterol, thus atherosclerosis can he prevented.更多还原