【摘要】 本文对60例经过3—4个疗程海群生(DEC)治疗后微丝蚴血症复现者用单剂量伊维菌素和标准疗程DEC的疗效比较。用随机抽样,双盲法进行实验。两种治疗组病人均出现完全而短暂的清除微丝蚴血症的作用。一年后,采用伊维菌素治疗组中7例复现微丝蚴血症,DEC组为5例,疗前微丝蚴密度高的患者,疗后一年微丝蚴血症复现也多。两治疗组的副作用均轻微,伊维菌素组常出现发热反应,DEC组则常出现淋巴丝虫病的局部反应。 我们认为伊维菌素是一种有效而实用、可替代DEC治疗班氏丝虫病微丝蚴血症复现者的药物。更多还原

【Abstract】 We compared the efficacy of a single dose of ivermectin with that of a standard course of diethylcarbamazine (DEC) for the control of microfilaremia in 60 patients with banrroftian filariasis who had developed recurrent microfiiaremia after each of three or more prior treatments with DEC.The study was done as a randomized,double-blind trial.Complete,but transient clearance of microfilaremia was observed in both treatment groups.One year later,recurrent microfilaremia was present in 7 patients treated with iVermectin and in 5 treated with DEC.Pretreatment levels of microfilaremia were significantly higher in patients who relapsed within one year after treatment than in those who remained amicrofilaremia.Side effects of either treatment were common but mild.Febrile reactions were more frequent in the ivermectin group: while localized reactions consistent with a flare up of acute filarial disease occurred mostly in the DEC group.We conclude that ivermectin is an effective and practical alternative to DEC for treatment of recurrent microfilaremia due to bancroftian filariasis.更多还原