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珊瑚红球菌降解胆甾醇制备雄甾-1,4-二烯-3,17-二酮的研究
STUDY ON DEGRADATION OF CHOLESTEROL TO ANDROSTA-1,4-DIENE-3,17-DIONE BY RHODOCOCCUS CORALLINA
【摘要】 珊瑚红球菌944-45选择性降解胆甾醇时,改变生物氧化条件(溶解氧、pH、种量、种龄、无机离子等)及投料方式,可提高雄甾-1,4-二烯-3,17-二酮(简称 ADD)的生成量。当底物浓度为0.25%,转化时间为94h 时,其 ADD 收率(GC 测定)最高约为37%。
【Abstract】 The effects of dissolved oxygen,pH age of the strain,the inoculated amount and Co+2,Fe+2on selective degradation of cholesterol by Rhodococo(?) corallina to produce androsta-1,4-diene-3,17-dione(ADD)were reported.When cholesterol was added in two separate times(total concentration 0.25%),the yield of ADD was 37%。
【关键词】 珊瑚红球菌;
雄甾-1,4-二烯-3,17-二酮;
胆甾醇;
【Key words】 androsta-1,4-diene-3,17-dione; cholesterol; Rhodocgccus corallina;
【Key words】 androsta-1,4-diene-3,17-dione; cholesterol; Rhodocgccus corallina;
- 【文献出处】 中国医药工业杂志 ,Chinese Journal of Pharmaceuticals , 编辑部邮箱 ,1992年05期
- 【被引频次】9
- 【下载频次】76