【摘要】 以对硝基苯甲酸为起始原料,改进了对甲胺基苯甲酰谷氨酸二钠的合成工艺,总收率由原工艺的12%提高到31%,降低了合成甲氨蝶呤的成本。更多还原

【Abstract】 The new process for synthesis of disodium p-methylaminobenzoyl-glutamate,using p-nitrobenzoic acid as starting material was described.The totalyield was raised from 12 to 31%,as compared with the original process and theproduction cost of methotrexate was reduced.更多还原