【摘要】 用巯甲丙脯酸(CPT)治疗8例糖尿病肾病(DN),经4～8周观察,尿蛋白降幅60.7±17.2％,但血尿素氮、肌酐均不同程度上升,治疗前后差异非常显著(P<0.01和P<0.01)。3例用药4周后,因严重氮质血症而终止治疗,2例6周后也终止治疗,1例第4周死于尿毒症,2例完成8周治疗。文内还讨论了巯甲丙脯酸加重糖尿病肾病氮质血症的原因。更多还原

【Abstract】 Eight cases of diabetic nephropathy were treated with Captopril for 4 ot 8 weeks, the results showed that the albu-minuria decreased 60.1 ± 17.2%, whereas the level of blood urea nitrogen and serum creatinine were increased in varying degrees. There were significant difference before and after treatment (P<0.01, P<0.01). Three of the patients had to be withdrawn from Captopril after 4 weeks of treatment, two of them had to be withdrown after 6 weeks, one of them died from uremia in the 4th week, only two cases went through the whole course of treatment for 8 weeks completely. Atter withdrawing irom Captopril for 2-4 weeks, the blood urea nitrogen and serum creatinine of the 5 cases returned to basic level. We suggest that Captopril-induced aggravation of azotemia may be related to glomerular efferent ar-teriolar hyalinosis and impaired auto-regulation of glomerular filtration in diabetic nephropathy.更多还原