节点文献

黄芪皂甙对离体工作心脏的肌力作用及其可能机制

Inotropic Action of Astragalus membranaceus Bge. Saponins and Its Possible Mechanism

  • 推荐 CAJ下载
  • PDF下载
  • 不支持迅雷等下载工具,请取消加速工具后下载。

【作者】 王奇玲李云义齐辉孙晓霞张文杰江岩

【Author】 Wang Qiling (Jilin Province, Central Hospital of Changehun City 130041) Li Yungi, Qi Hui, Sun Xiaoxia, Zhang Wengie and Jiang Yan(Norman Bethune University of Medical Sciences, Changchun 130001)

【机构】 吉林省长春市中心医院白求恩医科大学白求恩医科大学 130041长春 130021长春 130021

【摘要】 黄芪皂甙AMS,50~200μg/ml对离体工作鼠心有正性肌力作用,30μg/ml呈负性肌力作用,洗脱后恢复。毒毛旋花子甙K与高浓度AMS作用相似。AMS 500μg/ml使培养鼠心肌细胞静息电位减小10mV。提示AMS通过Na-K-ATP酶实现强心作用。

【Abstract】 Astragalus membranaceus saponins (AMS) 50~200μg/ml had a positive inotropic action on the isolated working heart of rats, but in the case of 30 μg/ml the inotropic action turned negative. The contractility recovered after washing out the AMS. Strophanthin K performed in a similar manner as AMS. AMS 500 μg/ml decreased the resting potential of cultured rat heart cells by 10 mV. The results suggest that AMS plays its inotropie role through influencing the Na-K-ATPase.

  • 【文献出处】 中国中药杂志 ,China Journal of Chinese Materia Medica , 编辑部邮箱 ,1992年09期
  • 【被引频次】196
  • 【下载频次】179
节点文献中: 

本文链接的文献网络图示:

本文的引文网络