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黄芪皂甙对离体工作心脏的肌力作用及其可能机制
Inotropic Action of Astragalus membranaceus Bge. Saponins and Its Possible Mechanism
【摘要】 黄芪皂甙AMS,50~200μg/ml对离体工作鼠心有正性肌力作用,30μg/ml呈负性肌力作用,洗脱后恢复。毒毛旋花子甙K与高浓度AMS作用相似。AMS 500μg/ml使培养鼠心肌细胞静息电位减小10mV。提示AMS通过Na-K-ATP酶实现强心作用。
【Abstract】 Astragalus membranaceus saponins (AMS) 50~200μg/ml had a positive inotropic action on the isolated working heart of rats, but in the case of 30 μg/ml the inotropic action turned negative. The contractility recovered after washing out the AMS. Strophanthin K performed in a similar manner as AMS. AMS 500 μg/ml decreased the resting potential of cultured rat heart cells by 10 mV. The results suggest that AMS plays its inotropie role through influencing the Na-K-ATPase.
【关键词】 黄芪皂甙;
离体工作心脏;
培养心肌细胞;
肌力作用;
静息电位;
【Key words】 Astragalus membranaceus saponins; isolated working heart; cultured cardiomyocvtes; inotropic action; resting potentials;
【Key words】 Astragalus membranaceus saponins; isolated working heart; cultured cardiomyocvtes; inotropic action; resting potentials;
- 【文献出处】 中国中药杂志 ,China Journal of Chinese Materia Medica , 编辑部邮箱 ,1992年09期
- 【被引频次】196
- 【下载频次】179