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丹参护肝机理的研究
Studies on Mechanisms of Protective Action of Radix Salviae Miltiorrhizae (RSM) against Experimental Hepatic Injury in Rats
【摘要】 实验结果表明,丹参能明显抑制正常及损伤肝细胞脂质过氧化反应,诱导细胞色素P450的合成,防止损伤肝细胞蛋白质、DNA、RNA、尿素及铜兰蛋白的降低,减轻肝毒物对体外培养肝细胞超微结构的损伤。
【Abstract】 The results indicated that RSM could significantly inhibit the lipid peroxidation of normal livers and cultured hcpatocytes of rats, induce liver microsomal cytochrome P450 in normal rats, increase nucleic acids, proteins, urea and cerolloplasmin of damaged cultured hepatocytes of rats, relieve ultrastructural damage of cultured hepatocytes induced by CCl4. The pharmacological actions mentioned above should be considered as important mechanisms of RSM against liver iniury.
【基金】 山西省科研基金
- 【文献出处】 中国中药杂志 ,China Journal of Chinese Materia Medica , 编辑部邮箱 ,1992年04期
- 【被引频次】67
- 【下载频次】158