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戊烷脒的反相离子对高效液相色谱测定方法
Determination of pentamidine in drug delivery system in vitro by ion-pair HPLC
【摘要】 本文用十二烷基磺酸钠及三乙胺配成 pH3的甲醇与水的溶剂系统作流动相,己烷眯为内标准,进行反相离子对高效液相色谱用于测定戊烷眯缓释制剂体外释放溶液中的含量。方法简便、特异、灵敏度高。
【Abstract】 A simple,sensitive and specific reversephaseion-pair high performance liquid chromatographywas developed for the determination of pentami-dine concentration in drug delivery system in vit-ro.The mobile phase was methanol-water(74:36v/v)containing 0. 004 M sodium laurye sul-fonate and 0.01 M triethylamine,with the pH ad-justed to 3.0 by phosphoric acid.Hexamidine wa-sused as the internal standard.
【关键词】 戊烷脒;
离子对高效液相色谱;
十二烷基磺酸钠;
三乙胺;
【Key words】 pentamidine; ion-pair HPLC; sodium laurye sulfonate; triethylamine;
【Key words】 pentamidine; ion-pair HPLC; sodium laurye sulfonate; triethylamine;
- 【文献出处】 中国药学杂志 ,Chinese Pharmaceutical Journal , 编辑部邮箱 ,1992年01期
- 【被引频次】1
- 【下载频次】6