【摘要】 肝细胞膜上的肝结合蛋白（HBP）是无唾液酸糖蛋白的受体。作者合成了无唾液酸糖蛋白的类似物—半乳糖新糖白蛋白（NGA）并用其作为肝靶向药物的载体,采用琥珀酸酐法与药物去甲替林（NT）偶联得NGA-NT。以此作模型化合物,经^99mTc标记后的动物放射显像及HPLC检测结果,说明NGA-NT在血中稳定,在肝脏降解释出NT,具有显著的趋肝性。更多还原

【Abstract】 Galactosyl-neoglycoalbumin（NGA） is a special ligand of asialoglycoprotein receptor which exists in the human liver. We used NGA as a carrier of hepatic targeting drugs and prepared a couple of NGA with Nortriptylin（NT） by succinyl bridge. The model compound was labelled with ^99mTc. The radionuclide image showed that the ^99mTc-NGA-NT had remarkable livertaxis.The result of HPLC revealed that the NGA-NT was stable in blood and released NT at the livers in tested rabbits.更多还原