【摘要】 2-甲氧基-6-羟基-7,8-二氢-5-喹啉羧酸甲酯(1)是石杉碱甲全合成中的关键中间体。本文报道从易得到的原料4-氧-1,7-庚二酸二甲酯(6)经四步反应合成(1)的新方法,总收率为39％。更多还原

【Abstract】 The title compound (1) is a key intermediate in the total synthesis of huperzine A. A new four-step synthetic method of (1) from readily available. 4-oxo-1,7-heptanedioic acid dimethyl ester (6)with 39％ overall yield was described in this paper.更多还原