【摘要】 高血压病(EH)患者有多种细胞膜钙运转异常。本研究用原子吸收法测定红细胞膜结合钙含量发现:(1)EH组(48例)值明显低于对照组(35例);分别为2.16±0.87和4.65±1.39μg/mg膜蛋白(P<0.01)。(2)不同期的高血压即Ⅰ期(12例)、Ⅱ期(26例)和Ⅲ期(10例),也显示膜结合量不同,分别力3.21±0.37、2.20±0.3和0.82±0.25μg/mg膜蛋白(P<0.01)。膜钙与收缩压、舒张压和平均压呈负相关,r分别为-0.795、-0.797和-0.883(P均<0.01)。(3)本研究所用膜钙测定方法简便、实用。因而。我们认为,膜钙降低不但对高血压发病膜缺陷机理探讨有益,而且对了解高血压病的程度有一定价值。更多还原

【Abstract】 Several abnormalities of calcium transport have been reported in human essential hypertension(EHT). Calcium binding capacity to erythrocyte membrane was measured in this study The results showed: (1) Calcium binding capacity was much lower in EHT (n=48) than in normal control(n=35) group, being 2.16 + 0.87 vs. 4.65 + 1.39μg/mg membrane protein (p<0.01); (2) EHT of stage Ⅰ (n=12), Ⅱ (n=26) and Ⅲ (n=10) group showed calcium binding capacity of 3.21 + 0.37, 2.20 + 0.30 and 0.82 ± 0.25μg/mg membrane protein, respectively (p<0.01); and calcium of erythrocyte membrane had negative correlation to SBP, DBP and (?)AP with r of -0.795, -0.797 and -0.883, respectively(all p<0.01); (3) The technique for measuring calcium binding capacity of erythrocyte membrane is simple and with practical value. A decrement of membrane binding capacity might not only be related to the development and maintenance of hypertension but also is very valuable in the clinical diagnosis of different stages of hypertension.更多还原