【摘要】 将 Sprague-Dawley 大鼠随机分为三组,分别用病区低硒粮饲料、病区粮加 Na₂SeO₃饲料和本校常规饲料喂养,用以研究克山病区低硒粮饲养动物心肌α₁受体变化及补硒的影响。实验结果发现,大鼠饲养两月时,常规饲料组大鼠心肌与〔³H〕哌唑嗪的最大结合量（Bmax）为01.90±36.97fmol/mg 蛋白;补硒组略有下降;低硒组则明显降低（P<0.05）。常规饲料组大鼠心肌α₁受体与〔³H〕哌唑嗪结合的平衡解离常数（KD 值）为2.25±0.08nM（?）补硒组仅有下降趋势;低硒组则明显降低（P<0.05）。反映克山病区低硒粮饲养可使大鼠心肌的α₁受体数量减少,受体与配体的亲和力降低。更多还原

【Abstract】 Sprague-Dawley rats fed respectively with Se-deficient diet （Se 0.010mg/kg）from Keshan disease area,Se-supplement diet（Se 0.180mg/kg）composed ofNa₂SeO₃ and endemic area cereals,and the stock diet （Se 0.121mg/kg） from theanimal center in Xi′an medical university were used to study the changes ofmyocardial α₁-receptor and the effects of Se-supplement.The results showedthat by the end of two months B max of（³H）-prazosin and myocardial α₁-adrenoceptor in the stock group was 101.90±36.97fmol/mg protein,B max inthe Se-supplement group showed a light loss,B max in the Se-deficient groupdecreased significantly （P<0.05）.KD of prazosin and myocardial α₁-receptor inthe stock group was 2.25±0.08nM,KD in the suPPlement group showed atendency to diminish,KD in the Se-deficient group was obviously diminished（P<0.05）.It indicates that the Se-deficient cereals from endemic area of Keshandisease would decrease the number of myocardial α₁-receptor and a affinitybetween the receptor and the ligand.更多还原