【摘要】 急性缺氧性肺血管收缩反应（HPV）具有重要的生理意义,前列腺素（PGs）和白三烯（LTs）参与了HPV的发生。本实验研究了中药成分毛冬青甲素对HPV的影响及其作用与PGs和LTs的关系。结果表明毛冬青甲素可增加基础肺血管阻力,减少心输出量,其作用一部分是通过增加LTs生成所致,而与PGs无明显关系。毛冬青甲素可增强HPV,其作用一方面是通过抑制Wistar大鼠缺氧时以舒血管性PGs（尤其是PGI₂）为主的PGs的产生,另一方面是通过增加LTs生成所致,也可能有其它机制参与。更多还原

【Abstract】 Acute hypoxic pulmonary vasoconstriction （HPV） plays an important role in physiological regulation. The purpose of this study was to explore the effects of Ilexonin A on hemodynamics and HPV, and their relation to prostaglandins (PG_?) and leukotrienes (LT_?).The results show that the high pulmonary vascular resistance induced by Ilexonin A in normoxic rats may be partially caused by the increased LTs and have no relation to PGs. Ilexonin A may potentiate HPV at least by two ways: replacing the production of PGs （especially PGI₂） in hypoxic Wistar rats, and increasing LTs production.更多还原