【摘要】 本文研究了蝮蛇抗栓酶对狗急性缺氧性肺动脉高压的作用。结果显示:蝮蛇抗栓酶可明显地降低肺循环阻力,剂量依赖性地减弱或抑制急性缺氧性肺血管收缩反应;但对体循环的影响较小,而且不改变PaO₂及PaCO₂;血浆6-keto-PGF_1α浓度在静脉注射此酶后明显升高,但TXB₂则无显著改变。这些结果提示:蝮蛇抗栓酶可缓解缺氧性肺血管收缩痉挛,其机制可能与促进PGI₂的产生与释放有关。更多还原

【Abstract】 The effect of ahalysantinfarctasum （AFT） on acute hypoxic pulmonary hypertension of dogs was examined. The’decrease in pulmonary vascular resistance and a dose dependent attenuation of acute hypoxic pulmonary vasoconstriction by AFT were found. AFT did not alter systemic vascular resistance. PaO₂ and PaCO₂ 6-keto-PGF_1α increased significantly, however after the intravenous infusion of AFT, TXB₂ did not change. It is suggested that AFT may attenuate hypoxic pulmonary vasoconstriction by tnducing the synthesis or release of PG I to nreyent nulmonary hypertension更多还原