【摘要】 采用抗S-100蛋白抗体技术,观察麻风病变中被破坏的神经纤维形态。发现52例中S-100蛋白染色有46例显示神经破坏,HE染色中22例阳性,皮肤结核病变用S-100蛋白染色也显示神经破坏,但在未出现干酪样坏死的皮肤结核灶内却很少见神经破坏,麻风与结核的神经破坏方式与形态也不尽相同。更多还原

【Abstract】 In order to observe the morphology of damaged n■e fibers of 59 cases with skin lesion of leposy, anti S-100 protein antibody combined with Avidin Biotin-Peroxidase Complex was used to label nerve fibers. The results showed that 46 of them showed destroyed nerve fibers by S—100 protein staining(positive rate 88.46%) and only 29 of them by HE staining (positive rate 42.30%). Significant difference presented between the two methods (x~2=9.412, P<0.01). Few damaged nerve fibers were seen in tuberculosis cutis focus of noncaseous necrosis. Pathomorphology of destroyed nerve fibers and destroying process of nerve fibers were not the same in leprosy and tuberculosis. The results showed that S-100 protein immunohistochemical technique is so valuable as to help diagnosis of leprosy and to enhance diagnostic rate of leprosy.更多还原