【摘要】 用离体的大鼠腹部皮肤研究盐酸普萘洛尔的经皮渗透过程,并分离出角质层进行吸附实验。结果表明,盐酸普萘洛尔在角质层内的吸附符合Langmuir吸附等温式,通过全皮的渗透系数和时滞随浓度提高而减小,而通过剥离角质层的活性皮肤渗透系数和时滞不受浓度影响。根据吸附扩散理论,提出了药物在角质层内渗透系数与浓度的关系式,讨论了浓度与时滞的关系。更多还原

【Abstract】 The sorption and rate of permeation of propranolol hydrochloride were measured asa function of drug concentration in the solution bathing rat skin in vitro. The sorption isotherm wasnonlinear, and can be expressed in Langmuir form. The lag time and apparent permeability coefficientthrough intact skin decreased as the concentration of donor compartment increased, and those throughstripped skin were not varied. These results indicate that an adsorption process existed when propra-nolol hydrochloride penetrated through the stratum corneum. Based on the adsorption- diffusiontheory, a mathematical formula was developed for expressing the relationship between the concentra-tion of drug and permeability coefficient through the skin quantitatively.更多还原