【摘要】 以QTc延长率为效应指标,用药代动力学-药效动力学结合模型对苦参碱、氧化苦参碱iv后在免体内的处置和效应动力学作定量分析,两药的血浓时程均符合二房室模型,两药的效应与效应室浓度之间的关系均符合S形E_max模型。两药彼此的药动学和药效学性质均有明显差异,但它们各自的劳动学和药效学性质在所用剂量范围内均为非剂量依赖性。更多还原

【Abstract】 On measuring the percentage of QTc interval prolongation, the pharmacokineticand pharmacodynamic profiles of iv matrine or oxymatrine in rabbits were analyzed by combined phar-macokinetic and pharmacodynamic model. The plasma concentration-time profiles of the two drugscan be described by a two-compartment open model, and the relationship between effect and effectcompartment concentration of both drugs can be represented by the sigmoid E_max model. Marked differ-ences in pharmacokinetic and pharmacodynanic parameters between the two drugs were found, buttheir pharmacokinetic and pharmacodynamic properties were dose-independent in the dose ranges usedin the experiment.更多还原