【摘要】 大鼠预先sc硝酸铋(30μmol·kg^-1·d^-1)连续3d,可显著降低肾毒性剂量顺铂(5mg·kg^-1)引起的尿蛋白含量,尿NAG活性和BUN水平的升高;并可有效地防护顺铂造成的肾脏髓层外带近端小管坏死,铋对肾脏MT合成有诱导作用,这可能与其防护顺铂的急性肾毒性有关。更多还原

【Abstract】 The protective effect of pretreatment with bismuth nitrate on acute renal toxicity by cisplatin was investigated in rats. Male rats received bismuth nitrate 30 μmol·kg-1 ·?d-1 sc for 3 d and a single dose of cisplatin 5 mg ·kg-1 ip on d 4. The pretreatment with bismuth significantly protected the rats from the cisplatin-induced rise in blood urea nitrogen and the widespread tubular necrosis in the S3 segment of the proximal tubule situated in the outer stripeof the medulla, although a minor transient increase of protein and NAG in the urinary excretion was observed. In comparison with the control, a single dose of cisplatin was unable to induce the synthesis of renal MT, while the pretreatment with bismuth resulted in a 5-fold increase in the content of renal MT. The results suggest that MT preinduced by bismuth may play an important role in the protection against the acute renal toxicity of cisplatin.更多还原