【摘要】 <正> 流行病学调查证明,长期食用鱼类的格陵兰爱斯基摩人心血管发病率较低,与鱼油含有n-3系多不饱和脂肪酸即二十碳五烯酸（eicosapentaenoic acid,EPA）,二十二碳六烯酸（docosahexaenoic acid,DHA）有关.据报道,鱼油具有调整血脂,抑制血小板聚集,延缓血栓形成等作用.本实验研究鱼油主要成分EPA对前列环素I₂（prostacycline I₂,PGI₂）更多还原

【Abstract】 In the biological assay, the rat arterial wall was incubated in a solution of Tris+EPA (0.5 mmol·L-1) and the rat platelet aggregation induced by ADP (5 μg·ml-1 PRP) could be inhibited by the solution. The inhibition rate was 63± s 19%, and that of the control (Tris+Na2CO3) was 29± s 11 %. The production of the PGI2-like substance could besignificantly raised by EPA (P<0.01,n = 6).The radioimmunoassay showed that EPA reduced the level of TXB2 and increased significantly 6-keto-PGFlαTXB2 ratio in the mouse plasma after the administration of EPA (10 mmol·L-1 EPA, 5μl·g-1, 5d,ip).更多还原