【摘要】 本文用[³H]环胞苷滴眼液（0.1%）给兔点眼,观察了它的眼内通遥性和眼内药代动力学。结果表明,环胞苷滴眼液点眼后迅速透入兔眼各组织,其中角膜浓度最高,其次为虹膜一睫状体、房水,品状体和玻璃体中浓度极低。测得角膜上皮渗透性为3.19×10^-4。各组织中药物浓度半衰期分别为:泪液0.04hr、角膜3.04hr、房水1.77hr。更多还原

【Abstract】 The intraocular penetration of Cyclocytidine（CC）was observed and pharmacokineticanalysis was performed following topically applying 3^H-labeled CC（0.1% eyedrop）torabbit eyes.The results showed that CC can rapidly penetrate into rabbit ocular tissues.The concentrational order was cornea,iris-cillary,aqueous humour.The highest concen-tration of CC was found in cornea.The concentration of the drug in lens and vitreouswas very low.The pharmacokinetic parameters were calculated with nonlinear least squaremethod by digital computer.The permeability of the corneal epithelial barrier（Kep）was3.19×10^-4.The half-life（t 1/2）of the tissue concentration was lacrimal fluid 0.04 hr,cornea 3.04 hr and aqueous humour 1.77 hr,respectively.The experiment indicates thatCC can maintain higher concentration in cornea,so it has good effect on HSV keratitis.更多还原