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视网膜下液视黄醇含量分析

Analysis of Retinol Content in the Subretinal Fluids from Retinal Detachment Patients

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【作者】 张晓光王桂云冀致敏李凤君韩岁梅

【Author】 Zhang Xiao-Guang,et al Department of Ophthalmology,The 2nd Clinical Hospital,Norman Bethune University of Medical Sciences,Chang Chun

【机构】 白求恩医大第二临床学院眼科白求恩医大预防医学院白求恩医大预防医学院 长春130041长春130041长春130041

【摘要】 用高效液相色谱测量20例网脱患者网膜下液及静脉血清中视黄醇含量,结果表明:网脱患者血清视黄醇含量为23.36ng/ml±4.16ng/ml,与正常人平均含量(19.59±1.29ng/ml)相比无显著差异(P>0.05);网膜下液视黄醇含量明显低于血清含量,约为血清含量的1/4~1/5。视黄醇含量变化与网膜裂孔大小,网脱范围及PVR 形成有关,与病程无关。视网膜色素上皮变性很可能是网膜格子样变性甚致引起网脱的重要原因之一。

【Abstract】 Retinol contents in the subretinal fluids from the retinal detachment patients wereanalized by using HPLC analizer and compared with some clinical signs of the patients.The results were as follows:1) there was no significant difference between the retinolcontent in the serum from retinal detachment patients and normal population (23.36ng/ml±4.16ng/ml to 19.59±1.29ng/ml, P>0.05);2) the retinol content in the subretinal fluidwas 1/5—1/4 of that in the patients’ serum (4.58ng/ml),and the variations of the retinolcontent was associated with the sizes of the retinal holes,extents of the retinal detach-ment and PVR formation,but not with duration of the diseases;3) the results suggestedthat the degeneration of retinal pigment epithelial cells may be one of the major cause(?)for the lattice degeneration of the retina and even for the retinal detachment.

  • 【文献出处】 眼科研究 ,Chinese Ophthalmic Research , 编辑部邮箱 ,1992年03期
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