【摘要】 iv10～20mg/kg(木解)皮素磷酸酯钾使兔急性心肌梗塞范围明显缩小,ST段明显降低,并能对抗冠脉结扎后引起的血清CPK含量增加及心律失常,这些作用与普萘洛尔相似。但iv40mg/kg后作用不明显。更多还原

【Abstract】 Potassium quercetin phosphate ( PQP, iv 10~20mg/kg ) significantly decreased the size of infarction and S-T segment elevation induced by coronary artery ligation in rabbits (P<0.05), meanwhile PQP could reduce the plasma CPK activity and ventricular arrhythmias induced by coronary artery ligation (P<0.05). These effects are similar to those of propranolol. But PQP (iv 40mg/kg) couldn’t obviously influence them. The above results suggeste that PQP ( iv 10~20mg/kg ) is beneficial and safe in limitation of EMI size and antiarrhythmia.更多还原