【摘要】 大鼠染锡矿尘后,肺组织脂质过氧化物水平和谷胱苷肽过氧化酶活性均显著高于对照组,肺组织细胞增生亦趋于活跃。锡矿尘所引起的这些反应与强致癌物3-MCA相似,绿茶能抑制此类反应。结果提示,脂质过氧化物增多可能是锡矿尘致肺损伤并诱发肺癌的机制中的一个重要环节,适当摄入绿茶作为抗氧化剂对降低锡矿工人肺癌高发可能具有重要意义。更多还原

【Abstract】 Previous studies have shown that tin mine dust had the potential of causing lung cancer; a role played by lipid peroxidation in inducing cancer has also been suggested. In this study, it was found that in experimental rats, 2～6 weeks after i. t. instillation of tin mine dust, the level of lipid peroxidation,the activity of glutathione peroxidase and the multipllcation of cells in lung were significantly [higher than that in control group. These effects of tin mine dust were in accord with that of 3-MCA, a positive carcinogen, while green tea could reduce these responses. The results suggested that the higher level of lipid peroxidation may be an important mediating factor for the pathogenesis of lung cancer of tin miners. Therefore, further measures for reduction of lipid peroxidation such as intake of green tea was considered to be helpful for reducing the incidence of Iung cancer.更多还原