【摘要】 作者采用费用效果和决策分析法,对山西乙肝疫苗接种前筛检策略进行了优化。结果表明,最优筛检方案是:先测抗-HBs,再对抗-HBs 阴性者测抗-HBc,二项均阴性者接种乙肝疫苗;这种“阶梯式”检测比常规方法筛检既往 HBV 感染者约节省费用1.87元/人。灵敏度分析表明,疫苗费和抗-HBc 检测费对策略优化较敏感。更多还原

【Abstract】 Based on cost-effectiveness analysis,a decision tree model was constructed to evaluate the 16 kinds of projects for screening hepatitis B virus markers before vaccination.The alternative in which the negatives for anti-HBe are identified after testing for anti-HBs. Vaccinating all the test negatives was found to be the most cost effective.Almost 1.87 yuan per person can be saved by using this strategy than by using the common screening approach.Sensitivity analysis was used to determine the influence of the parameters on the decision making.更多还原