【摘要】 测定了8只健康奶山羊和其功能性肾组织减少75％时的肾清除率以及快速静注SM₂的药代动力学参数。结果表明,后者肾功能比正常平均减小约66％;药—时曲线从C_正常=5.5e^-6.5376t+24.29e^-0.2162t改变为C_肾功减退=6.78e^-4.958t+23.02e^-0.1425t.其他动力学参数与健康时比较t_1/2β延长了75％;AUC增加了49％;t_CP（ther）延长了52％,但β和Cl_β显著降低（P<0.01）。多次静注的药动学研究表明,其血药浓度同单剂量推算的结果没有差异。更多还原

【Abstract】 The renal clearance and the parameters of pharacokinetics of Sulfadimidine were determined in 8 milk goats with their renals in normal functions, and then 75% of reduction in reanal functions were determined by giving fast intravenous injections of SM2- The results indicated that the mean reduction in renal functions of the latter was approximately 66% lower than that in normal ones. The blood concentration time equations of the drug varied from Cnormal = 5.5e-65376t+24.29-0.2162t to C reduced = 6.78e-4958t+23.02e-0.1425T. In comparison of other parameters of pharama-cokinetics in milk goats with reduced renal functions with those in health milk goats, tprolonged 75%; A∪C increased by 49%; tcp (ther) prolonged 52%; but β and Clβ, decreased significantly (P<0,01). Also, the studies of multiple intravenous injections of pharacokinetics of SM2 indicated that there was no difference between the blood concentration of SM2 and the deduced results with single dosage.更多还原