【摘要】 20只Wistar断奶雌性大鼠随机分为酒精组、铁组,酒精/铁组和对照组。12个月后剖杀所有大鼠,取肝脏作电镜观察,用原子吸收分光光度计作肝内铁含量测定。结果表明,试验各组肝铁含量比对照组高8～15倍;超微病变为细胞核皱缩和异常;线粒体肿大变形,粗面内质网扩张和脂滴形成;枯否氏细胞和肝细胞内含大量铁质沉着体,多数沉积于溶酶体内;肝淋巴间隙和肝窦内有胶原束。更多还原

【Abstract】 Twenty Wistar female weaning rats were used for experimental lexicological stusy of over-load iron and alcohol. They were divided into three trial groups (i.e. alcohol group, iron group and alcohol / iron group) and one control group. All rats were slaughted 12 months later. Their livers were investigated by electron microscope and hepatic iron concentration was measured by Atomic Absorption Spectrometer. The results showed that the hepatic iron concentration in trial groups was H- 15 times as high as that in the control grop. The ultrastructural changes included nuclear pyknosis and abnormalities, mitochondrial swelling, dilatation of rough endoplasmic reticulum and lipid droplets. Numbers of electron dense (Fe) which was present within lysosomes occurred in hepatocytes and Kupffer cells. Collagen bundles presented in some sinusoids and Disser’s spaces.更多还原