【摘要】 本文对比测定了克山病病区与非病区儿童血小板GSH_px、SOD活性和cAMP水平,以及全血、红细胞、血浆和头发硒含量。结果表明,病区儿童血和发硒均明显低于非病区;血小板GSH_px活性比非病区儿童显著低下,但血小板SOD活性和cAMP水平无显著差异。提示病区低硒儿童血小板GSH_px活性的降低可能导致血小板功能和代谢的改变。更多还原

【Abstract】 In the present study, platelet GSH_px, SOD activities and cAMP contents, as well as whole blood, erythrocyte, plasma and hair selenium levels were comparatively measured in children from Keshan disease endemic and non-endemic areas. The results showed that blood and hair selenium contents were significantly lower in children of the endemic area than in those of the non-endemic area; children in the endemic area had a signifi cantly lower platelet GSH_px activities as compared to those in the non-endemic area, but no remarkable difference of platelet SOD activities and cAMP contents between children in the two areas was observed. The results indicate that the reduced GSH_px activity of low-selenium children in the endemic area may result in alterations in platelet functions and arachidonic acid metabolism.更多还原