【摘要】 用放射免疫分析法测定大鼠离体黄体细胞孕酮含量,观察了人工合成的12种小分子肽对大鼠黄体细胞的影响。结果表明,Gly-Tyr-NH₂和Gly-Ser-Lys 有抑制黄体细胞基础孕酮分泌作用,还抑制hCG 诱导的孕酮分泌;Lys-Tyr-NH₂,Thr-Ser-Lys,Gly-Tyr-Lys 抑制hCG 诱导的孕酮分泌;（Gly-Tyr）₂=Lys 则增强基础及hCG 诱导的孕酮分泌;其余6种小分子肽（Gly-Gly,Gly-D—Tyr,Tyr-D—Tyr,Thr-Ser-Tyr,Thr-Asn-Tyr-Thr-NH₂,Tyr-Tyr-His-Lys-Ser）,对大鼠黄体细胞孕酮分泌没有影响。同时讨论了其构效关系及可能的作用机制。更多还原

【Abstract】 The effects of 12 synthetic small peptides on progesterone（P）production in corpus lu-teal cells were investigated by RIA.The results showed that Gly-Tyr-NH₂ andGly-Ser-Lys inhibited both basal and hCG-induced（P）production,Lys-Tyr-NH₂,Thr-SerLys and Gly-Tyr-Lys decreased only hCG-induced（P）production,（Gly-Tyr）₂=Lys enhan-ced basal as weU as hCG-induced（P）production,and the others（Gly-Gly,Gly-D-Tyr,Thr-Ser-Tyr,Thr-Asn-Tyr-Thr-NH₂,Tyr-Tyr-His-Lys-Ser）exhibited no significantinfluence on（P）production by rat luteal cells.The structure-bioactivity relationshipwas also discussed.更多还原