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抗枯宁的致突变性和致畸性研究

STUDIES ON THE MUTAGENIC!TY AND TERATOGENICITY OF KANGKUNING

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【作者】 孙天佑; 谭佩娇; 刘志艳; 白桂花; 沈松筠;

【Author】 Sun Tianyou, et al (Dept. of Industrial Hygiene)

【机构】 山西医学院预防医学系; 山西医学院预防医学系;

【摘要】 本文报道抗枯宁的致突变性和致畸性实验结果。结果表明,抗枯宁在Ames试验中,加和不加S99A98和A100菌株回变菌落数均未超过自然回变菌落数的2倍,小鼠骨髓嗜多染红细胞微核试验和精子畸形试验结果阴性;抗枯宁没有致畸胎作用。

【Abstract】 This paper reported the results of mutagenicite and teratogenicitic tests of Kangkuning. They showed that Kangkuning did not induce positive mutations of strains (TA98 and TA100) with or without S9 mix in the Ames test; there was no increase of micronucleus rate of polychromatic erythrocytes in mouse marrow; It did not increase morphological abnormality rate of sperm in mice; Kangkuning did not have teratogenises.

【关键词】 抗枮宁; 诱变性试验; 致畸胎作用;
【Key words】 Kankuning; mutagenicity; teratagenicity;
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