【摘要】 实验在55只乌拉坦麻醉、制动、人工呼吸及切断双侧颈迷走神经的家兔上进行。结果如下:双侧蓝斑复合核(Lc-Sc)区注射胞体兴奋剂L-谷氨酸钠(L-Glu)100μg/μl,使呼吸频率(RF)、膈神经放电频率(PhrD)明显增加(P<0.01及0.05),吸气时程、呼气时程均缩短,动脉血压无明显变化。于双侧孤束核(NTS)区分别预注射哌唑嗪(0.5μg/μl)、育亨宾(4μg/μl)、心得安(2μg/μl)可阻断L-Glu的上述效应。实验结果提示,Lc-Sc区对呼吸具有兴奋作用,其增加RF的效应是通过NTS区的α和β受体实现的,而使PhrD增加的机制则有所不同。更多还原

【Abstract】 Experiments were performed on 55 urethane anesthetized and flaxedil im-mobilized rabbits under artificial respiration. Injection of L-Glutamate into thelocus coeruleus area led to a marked augmentation of respiration. This effect ofL-Glutamate could be significantly attenuated or reversed by a previous injectionof prazosin, yohimbine and propranolol into the NTS area. These results indicate that the neurons in the locus coeruleus are involvedin the regulation of the respiration as a result of madiation by alpha and beta re-ceptors in the NTS area.更多还原