【摘要】 用体外实验方法,以人红白血病K562,人胃癌细胞株SGC-7901为靶细胞,研究丁胱亚磺酰亚胺(BSO)对人体肿瘤细胞的直接杀伤及BSO与顺氯氨铂(DDP)或5-氟尿嘧啶(5Fu)联合应用的增敏作用。结果表明BSO单用或与DDP、5Fu联合应用对K562和SGC-7901均有明显的杀伤作用。更多还原

【Abstract】 Buthionine sulfoximine (BSO), a selective inhibitor of r-glutamyloysteine synthetase and thus an inhibitor of GSH (Glutathione) biosynthesis, has been studied as a ohemosensitizer.We have investigated its effect on two human tumor cell lines in vitro. The results showed that BSO(0.01-50μg/ml) had remarkable oytostatio activity on human leukemia K 562 and human gastric cancer SGC-7901.As a ehemosensitizer, it may potentiate or enhance their antitumour activity on K 562 and SGG-7901 when used in combination with fluorouracil (5 FU) or ois-diaminediohloroplatin (DDP). On the basis of these data, we reoommend further preolinioal study.更多还原