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党参、蒲公英、川芎及其配伍对大鼠胃粘膜损伤的保护作用

Protective Effects of Codonpsis Pilosula, Taraxacum Mongolicum, Ligusticum Chuanxiong and Their Formula on Gastric Mucosa

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【作者】 黄萍王建华劳绍贤

【Author】 Huang Ping Institute of Clinical Pharmacology

【机构】 广州中医学院临床药理研究所

【摘要】 本文首次采用肉眼和组织学同步观察的方法,观察了健脾、清热、化瘀的代表中药党参、蒲公英,川芎对胃粘膜的保护作用。结果表明,肉眼观察三药及其配伍对胃粘膜均有良好的保护作用,量效间依赖关系良好;组织学观察则发现,党参和三药配伍组成的复方对胃粘膜有良好的保护作用,而川芎和蒲公英的保护作用不明显。这提示了在胃粘膜保护的研究中组织学观察的意义。

【Abstract】 This paper reported for the first time, thw pharmacologica! effects of Codonopsis Pilosula(CP), Taraxacum Mongolicum(TM), Ligusticum Chuanxiong (LC) and their formula on protecting gastric mucosa in model rats, which were observed macroscopically and microscopically. The results by macroscopic inspection showed that CP, TM, IC and their formula could markedly lessen gastric mucosa injury induced by ethanol and the lesion indexes of the gastric mucosa were markedly decreased. Besides, the effects also showed a doseeffect relation. By microscopic inspection, it was found that gastric mucosa could be protected by CP or by the formula of the three herbs, but no protective effect on gastric mucosa was found by IC or TM.

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