【摘要】 对正常和肝硬化大白鼠作肝部分切除(38±4%)术,观察合并脾切除、脾血管结扎(保留脾上极血管)及不切除脾脏,对残肝再生的影响。脾切除、脾血管结扎组的肝再生率、核分裂指数、核标记指数、DNA 含量,均显著高于不切除脾脏组。电镜显示脾切组肝细胞的粗面内质网、线粒体、糖原增多,较对照组更为明显。硬化肝切除合并脾切除术后残肝伊藤氏细胞转变为纤维细胞明显减少。结果证实脾切除后能够明显促进肝再生并降低肝硬化的硬变程度,存留20%的正常脾组织对肝再生可无抑制作用。更多还原

【Abstract】 The effect of splenectomy,splentic vessels tied(the superior vesselsreserved)and non-splenectomy on liver regeneration after partial hepatotomy(38±4%)of normal and cirrhosis rats has been observed.In the splenecto-mized rats and splenic vessels tied rats,the percentage rate of liver regene-ration,nitotic nucleic index and content of DNA were higher than in non-splenectomy.Under electromicroscope observation,the rough surfaced endo-plasmic reticulum,the mitochondrion and glycogen were also significantlyincreased.The itol cells of the liver remainder changed to fibrocytes wereremarkably decreased by splenetomy with liver cirrhosis.The results suggestedthat the liver regeneration would be promoted greatly and degree of livercirrhosis decreaced by:splenectomy.The 20% remaining normal splentictissue wouldnot inhibit the liver regeneration.更多还原