【摘要】 作者对临床分离的243株11种眼部病原菌进行氟哌酸及一组眼科常用抗菌剂的体外药物敏感试验。结果表明,抗菌谱及敏感率氟哌酸明显优于其他对照组抗生素(Ridit 值 X~2=309.4,X~2(5)=16.75,P<0.005),依次为:氟哌酸、庆大霉素、卡那霉素、氯霉素、青霉素。对于铜绿假单胞菌,氟哌酸与庆大霉素同样有效,而对于金黄色萄葡球菌尤其是醋酸钙不动杆菌,氟哌酸的抑菌效力比庆大霉素强。结合其良好的组织分布和低毒特性,氟哌酸不失为治疗眼部表浅感染的最佳选择。更多还原

【Abstract】 In vitro drug sensitive test of norfloxacin and a group of common antibacterial agents was carried out in 243 isolates representing 11 species in ocular infections.On the inhibitory diameter data,norfloxacin is more sensitive than the others tested (Ridit norfloxacin=0.695,x~2=309.4,x~2(5)0.005=16.75,P<0.005).Norfloxacin is equal to gentamicin in sensitivity to Pseudomonas aeruginosa and more sensitive than gentamicin to Staphylococcus aureus,especially,Acinetobacter calcoaceticus.Norfloxacin is suggested to be the best selection for superficial bacterial infection of the eye.更多还原