【摘要】 用国产甲氟哌酸(PF)对14例新发多菌型麻风治疗6个月,临床、皮肤查菌、组织病理学和菌血症检查均有明显进步。对其中9例于治疗前后测定麻风菌的活力,显示治疗1个月有2例繁殖,2和3个月时则均耒见繁殖。2例BL分别治疗6和12个月停药,前者停药10个月、后者停药4个月随访时病情恶化,提示治疗不足或有产生耐PF菌株的可能性。更多还原

【Abstract】 Fourteen newly detected MB cases of leprosy have been treated with pefloxacin made in China for six months and have got significant improvement clinically,bacteriologically and pathologically.Among nine cases out of these patients, the vitality of the bacilli was measured before and after treatment.The bacilli in two cases showed still multiplication at the end of the first month of treatment,but no proliferation at the end of the second and third month.Two BT cases have been treated for six and 12 months,and when followed --up four and ten months after stop of treatment respectively, their conditions showed deterioration,suggesting that the treatment was not sufficient or the drug resistance has be indued更多还原