【摘要】 本文对44例MDS患者的多向祖细胞(CFU—GEMM)、红系祖细胞(BFU—E)、前巨核祖细胞(BFU—MK)、后巨核祖细胞(CFU—MK)、粒系祖细胞(CFU—GM)进行了体外培养观察。结果表明部分MDS骨髓粒系祖细胞体外生长类似白血病生长型。其它各系祖细胞集落数量减少,且明显小于正常,说明祖细胞在增殖分化等方面有明显的缺陷。更多还原

【Abstract】 In the present report we studied the CFU-GEMM, BFU-E.BEU-MK, CFU-MK and CFU-GM progenitors in MDS. The results demo-nstrated that the CFU-GM growth patients of some MDS patients weresimilar to leukemic growth patterns. The other progenitor cell growth sh-owed that the number of the colonies were decreased and the size of thecolonies were significantly smaller than normal colonics. These suggestthat the proliferation and differentiation of the progenitors are signific-antly defective.更多还原