【摘要】 以滇产毛喉鞘蕊花为主药拟定的平喘止咳口服液,相当于175g/kg单次ig小鼠,有短时毒性反应,无死亡,35g/kgig无异常。大鼠60天30、15、10g/kg重复给药后动物活动、行为、体重增长、血液学及生化测定均属正常。肝、肾、肺、心、脑组织病理学检查,仅散在点、灶状性肝细胞坏死,发生率较对照组多。麻醉兔十二指肠给予5,10g/kg剂量,呼吸及腺体分泌、血压、ECG和EEG等未见明显改变。本文为临床推荐剂量0.6g/kg安全性提供了依据。更多还原

【Abstract】 Coleus forskohlii oral solution is a composite preparation containing several effective constituents of the plant, such as isoforskolin, 1-acetylforskolin etc.Following ig administration of the oral solution equivalent to≤35 g (raw herb)/kg to mice, neither toxic reaction nor death was observed. After the oral solution 30, 15, 10 g/(kg·d)×60 ig to rats, their appearance, body weight, and hematological, biochemical and pathological investigations were basically normal. In anesthetized rabbits intraduodenally administered the oral solution≤10g/kg, the respiration, airway secretion, blood pressure, ECG and EEG did not change significantly.These results indicate that Coleus forskohlii oral solution is a quite safe preparation.更多还原