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蜱抗原诱导的宿主免疫力的研究
Studies on Induced Host Immunity by Haemaphysalis Bispinosa Antigens
【摘要】 报道在实验室控制条件下,用二棘血蜱叮咬家兔诱导其产生获得性免疫力。结果表示:叮咬组家兔经 ELISA 法测定其体内抗体(OD 值0.54),较对照组(OD 值0.09)有显著升高(P<0.01),叮咬家兔后其~3H—TdR 淋巴细胞转化试验的 PHA 刺激指数为67.11±35.16,较对照组15.49±14.53.有显著升高(P<0.01);另外,两组的皮肤试验也有极显著差异。(P<0.001),表明家兔对二棘血蜱叮咬所产生的获得性免疫力不仅与宿主的体液免疫有关,同时也与宿主的细胞免疫有关。
【Abstract】 This report deals with acquired immunity of rabbits induced by Haemaphysalis bispiuosa infesta- tion in laboratory under controlled conditions.The results showed that the antibody level(OD:0.54)of infested rabbits was higher than that of the control group (OD:0.09)with ELISA detection (P<0. 01).The PHA index of stimulation sith ~3H-TdR lymphocyte transformation test of infested rabbits was 67.11±35.16,significantly higher than that of the control group (15.49±14.53)(P<0.01).In addition,the skin test showed significant difference between the two groups (P<0.001).It suggests that the acquired immunity of rabbits,induced by Haemaphysalis bispinosa,is associated with not only the host’s humoral but also cellular immunity.
【Key words】 antigen; immune responce; lymphocyte transformation; comparative study; animals; laboratory; ticks; rabbits;
- 【文献出处】 江西医学院学报 ,Acta Academiae Medicinae Jiangxi , 编辑部邮箱 ,1992年03期
- 【分类号】R384.3
- 【被引频次】1
- 【下载频次】21