【摘要】 本文报道一为期1年的随机自身对照临床试验,观察连续使用每月一次的复方庚炔诺酮长效避孕针(HRP102组,33例)与复方醋酸甲孕酮避孕针(HRP112组,31例)对于糖代谢及肝功能的影响。口服葡萄糖耐量试验结果:连续用针9个月后两组血浆葡萄糖水平均有轻度升高,HRP102组糖耐量反应曲线下面积较用针前增加19.9%(P<0.01),HRP112组增加4.5%。停针3个月均迅速恢复至用针前水平。两组口服葡萄糖胰岛素释放试验的结果类似,用针9个月后基础血浆免疫活性胰岛素均由用针前的14.0pmol/L上升到21.0pmol/L(P<0.01),胰岛素反应曲线达峰后下降变缓,曲线下面积相应增加。停针3个月胰岛素虽未恢复至用针前水平,但测定值均在正常范围,故并无临床病理意义。肝功能指标中,谷丙转氨酶、谷草转氨酶、谷肽转氨酶、碱性磷酸酶的活性在用针前后均无异常。在用针9个月两组分别有9例与8例呈现总胆红素升高,提示可能影响部分对象的胆汁分泌。更多还原

【Abstract】 In order to determine the possible effects of two monthly injectable contraceptives-norethisterone enanthate 50mg plus estradiol valerate 5mg (HRP 102)and medroxyprogesterone acetate 25mg plus estradiol cypionate 5mg (HRP 1 12)on carbohydrate metabolism and liver function, plasma glucose, insulin concentrations and serum ALT, AST,GGT, ALP,bilirubin levels were studied in 2 groups of women who received continuously HRP 102 (33 cases) and HRP 112 (31 cases) for 9 months,and followed by 3 months after stopping of administration. Plasma glucose and area under OGTT curve showed slight increase 9 months after treatment in both groups,then returned to pretreatment levels after stopping of use. subjects in both groups showed siginificantly increased OGTT insulin levels (IRI to pretreatment (14.0pmol/Lvs 21. 0pmol/L,p<0.01). Although 1R1 levels remained higher in both groups post treatment,all valuse of 1R1 were in normal range. All liver funciton parameters showed no changes after treatment in both groups with the exception of bilirubin test. The increased bilirubin levels may suggest the interference of bile secretion in some individual of users after using steriodal contraceptives.更多还原