【摘要】 本文采用荧光组织化学法,对25例喉癌患者进行雌、孕激素受体检测,结果发现雌激素受体阳性12例占48%,孕激素受体阳性17例占68%,受体水平与喉癌分化程度有关,分化程度越低,受体含量越少。研究表明:喉癌细胞存在有雌、孕激素受体,性激素受体与喉癌发病可能有关。更多还原

【Abstract】 The existence of hormonereceptors on or within neoplastic tissuehas potential diagnostic, therapeutic, andprognostic importance. It has now beendemonstrated in many reports that cancersof the breast and prostate often expresshormone receptors and can be controlledby hormone manipulation. The fact thatlarynx is a target organ for androgenicsteroids has long been known. The questionof whather laryngeal carcinoma expres-ses hormone receptors has been a matterof interest. We adopted the fluorescenthormone conjugate methed to measure theestrogen receptor (ER) and progesteronereceptor (PR) in 25 patients with laryngealcancer. Our findings indicated that in 25samples of laryngeal cancer 48% were ERpositive,and 68% were PR positive. Cells ofthe laryngeal cancer not only contain ER andPR but also have relationship between thepresence of receptors and the degree ofhistologic differentiation. Low differentiatedcancers are inclinable to contain low levelreceptors. From this initial survey it ap-pears that the hormone receptors could playan important role in the cancer of larynx.The presence of receptors in some laryn-geal carcinoma implicates that these tumorsare possibly hormone sensitive.更多还原