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胎肝细胞悬液输注对恶性肿瘤患者巨噬细胞吞噬功能的影响

Effect of fetal liver suspension transfusion on the phagocytosis of the macrophages in patients with malignant tumors

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【作者】 祁岩超卜夏王燕芳赵鹏王守章周浩本万俊邵梦扬

【Author】 Qi Yanchao, Pu Xia, Wang Yanfang Zhao Peng (Henan Institute of Oncology) Wang Shouzhang, Zhou Haoben, Wan Jun Shao Mengyang (Henan Tumor Hospital)

【机构】 河南省肿瘤研究所河南省肿瘤医院河南省肿瘤医院

【摘要】 报道45例常规化学药物治疗辅以胎肝细胞输注(FLT)的恶性肿瘤患者和60例单纯常规化学药物治疗的恶性肿瘤患者的巨噬细胞吞噬功能变化。结果表明:FLT可以保护和提高恶性肿瘤患者的巨噬细胞吞噬功能,避免化疗药物引起的免疫功能下降,是一种恶性肿瘤化疗中的有效的辅助疗法,有一定的临床应用价值。

【Abstract】 The immunity of the patients with malignant tumors (PMTs) is generally suppressed and injured to some degree, especially during the treatment with chemotherapy. In order to prevent the PMTs during the treatment with chemotherapy from the injury of immunity, we have studied the effect of fetal liver cell transfusion (FLT) on the phagocytosis of macrophages (PhM) in 45 PMTs treated with chemotherapy supplemented by FLT, and 60 PMTs treated with chemotherapy supplemented by ginseng root sap (GRS). The result showed that the PhM—elevating rate of PMTs in the FLT group is 89.9% (40/45), significantly higher than that (63.3%) in the GRS group (38/60) (P<0.01). To sum up, our data suggest that FLT has an obvious irritant function to elevate the PhM in the PMTs, i. e, FLT can elevate the immunity of the PMTs, and it is more effetive than GRS. Therefore, FLT is a useful supplemtary immunological method in the chemotherapy of PMTs.

【关键词】 肿瘤免疫吞噬
【Key words】 tumorimmunityphagocytosis
  • 【分类号】R730.51
  • 【被引频次】1
  • 【下载频次】33
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