【摘要】 应用超氧物歧化酶(SOD)及其抑制剂二乙基二硫氨基甲酸钠(DDC)分别在甲基胆蒽(MCA)碘油诱发 Wistar 大鼠肺鳞癌的过程中应用,以探索 SOD,DDC 与发癌之间的关系。发现 DDC组14只大鼠,在35d 诱癌过程中,出现2例肺鳞癌.2例支气管上皮呈不典型增生,而正常对照组11只仅出现1例不典型增生。SOD 组14只大鼠中未出现肺癌及不典型增生。结果表明,DDC 与化学致癌物质 MCA 诱癌有协同作用,并使诱发性肺癌提前发生.SOD 可能有抑制肺癌发生的作用。最后还对其作用机理进行了讨论。更多还原

【Abstract】 The squmous cell carcinoma of Iung was induced with methylcholanthrene solved in iodized oii (MCA)in wistar rats.During the development of the cancer,the animals were given superoxide dismutase(SOD)and diethyldithiocarbamate(DDC)respectively,In DDC group composed of 14 rats.2 developed the cancer and 2 developed atypical hyperplasia of bronchial epithelium within 35 days,In SOD group,all of the 14 rats had no cancer and atypical hyperplasia in lungs,in 11 rats of the control,only one rat had atypical hyperplasia of the bronchial epithelium.The results suggested that there was a cooperation between DDC and MAC in inducement of tung cancer,and the duration of cancer development was shortened;SOD might be an inhibitor of development of lung cancer.The mechanism of the effect of SOD and DDC was discussed.更多还原