【摘要】 本文报道小剂量尼群地平静脉注射观察其对急性低氧性肺动脉高压(猪)的降压作用及其对血流动力学的影响,结果显示:小剂量尼群地平静注能降低急性低氧所致肺动脉高压,降低肺循环血管阻力,其降压作用超过6小时,并能减轻右心负荷,增加氧的输送能力,对心肌和体循环动力学无明显影响,进一步深入研究尼群地平的作用,有希望提供临床作为降低肺动脉高压的药物使用.更多还原

【Abstract】 As pulmonary vasoconstriction is a majior factor producing pulmonary hypertension duing hy- poxia.It can be Inhibited or attenuated by calcium channel blocking agents,we evaluated the ef- fects of nitrendipint on the hemodynamics of pulmmonary and systemic circulation in seven pigs. Animals were anesthized with intravenous injection of pentothal（10 mg/kg）,and vetilated with a Servo-900 C ventilator.The hemodynamics of pulmonary or systemic circulaion were continuously monitored by IVY 410 monitor via a Swan-Ganz and arterial catheter.Minute ventalaion and inspi- rated oxygen concentration were adjusted to maintain a stable PaO₂ and PaCO₂,cardiac output（CO） systemic pressure and pulmonary arterial prepare were measured during normoxia （PaO₂14.95± 0.78 kpa）hypoxia （PaO₂5.97±0.35 kpa） and hypoxla with nitrendipine injection （100 ug/kg iv）.During 15--16% oxygen Ventilation the mean pulmonary anry pressure （PAPm）,pul- monary vasocular resistnce （PVR）,right ventricle work index （RVWI） increased all P<0.05. After a single dose of 100 ug/kg of nitrendipne iv,PAP dropped from 4.2±0.19 to 3.18±0.17 kpa,PVR from 46.3±7.1 to 32.2±3.7kpa,L/s RVWI from 17.8±2.4 to 15.4±2.5 J/m2 all P<0.05.Co（L/min） rose from 5.09±0.66 to 5.6±0.72.This response lasted more than six hours.Oxygen delivery also improved.Meanwhile systemic pressure remained unchanged.The data suggests that nitrendipine release,hypoxia induced pulmonary hypertension and improves oxy- gen transport in pigs.更多还原