【摘要】 我们用二批猪制备低氧性肺动脉高压模型:分批观察了克甫定(Captopril)和尼群地平(Nitrendipine)对循环血流动力学的影响,及动脉血中血管紧张素转换酶(ACE)的活性,结果显示小剂量尼群地平对低氧性肺动脉高压降压作用远强于克甫定,而对ACE的活性,克甫定注射后显著下降而尼群地平对其几无影响。更多还原

【Abstract】 The studies of hypoxia induced pulmonary hypertension in pigs were divided two groups （n 9, n 7）, A Swan-Ganz Catheter and an arteria catheter were inserted into the pulmonary artery and capillary wedge pressure （PCWP）, cardiac output （CO）, Blood pressure （BP） were monitored before and after hypoxia and captopril and nitrendipine injection （7 mg/kg and 100 μg/kg） respectively, angiotensin converting enzyme （ACE） was measured by fluorometry. Results showed that during hypoxia PAP in all the pigs were increased significantly. P<0. 05 compared with normoxia and after captopril and nitrendipine intravenous in jection, the PAP were dropped significantly （from 3. 76±0. 25 to 3. 43±0. 1 kpa Versus from 4. 21±0. 19 to 3. 18± 0. 17 kpa nitendipine） respectivetly. Both P<0. 05. ACE in captopril group was significant reduced p<0. 05 (58±4 to 27±3umol. min^-1/L),but in nitrendipine group ACE was not marked change P>0. 05 compared with the effect of captopril and nitrendipine on the hemodynamics of pigs with acute hypoxic pulmonary hypertension. We found that reducing the degree of PAP and its duration time, lowered the pulmonary vasocular resistance （PVR） and right ventricle stroke work Index （RVSWI）. Also improved capacity of oxygen delivery, nitrendipine was better than captopril may be it is a useful drug for patients with pulmonary hypertension.更多还原