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抗凝血肝素化聚(醚—酰胺胺—脲—氨酯)的研究
Blood Anticoagulating Heparinized Poly (ether-amidoamine-urea-urethane)
【摘要】 合成了一种含有聚酰胺胺链段的聚(醚—酰胺胺—脲—氨酯)(PEAUU)嵌段共聚物。这种嵌段共聚物较诸相应的聚酰胺胺,有较好的机械性能和对稀酸、稀碱以及生理盐水的良好稳定性。体外试验表明,它本身就具有良好的抗凝血性,经过肝素处理,PEAUU表面与肝素形成了聚电解质复合物,抗凝血性能又有进一步提高。
【Abstract】 A block copolymer of poly(ether--amidoamine-urea-urethane)(PEAUU) con-taining polyamidoamine segment was synthesized. This block copolymer possesses im-proved mechanical properties and far more resistant toward hydrolytic degradation ofdilute acid and base as compared to polyamidoamine. vitro tests demonstrated,PEAUU itself, and especially after heparinization, has excellent blood anticoagulatingproperty.
【关键词】 聚酰胺胺;
聚(醚-酰胺胺-脲-氨酯);
嵌段共聚物;
肝素化;
抗凝血;
【Key words】 poly amidoamine; poly (ether-amidoamine-urea-urethan); block copolymer; heparinization; blood anticoagulating;
【Key words】 poly amidoamine; poly (ether-amidoamine-urea-urethan); block copolymer; heparinization; blood anticoagulating;
- 【文献出处】 功能高分子学报 ,Journal of Functional Polymers , 编辑部邮箱 ,1992年04期
- 【被引频次】9
- 【下载频次】69