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酮替芬对感染伯氏疟原虫小鼠血清维生素A,C,E含量的影响

Effect of Ketolfen on Serum Vitamin A, C, E in Mice Infected with P. Berghei

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【作者】 邬大元王静陈鸿基翁幼萍

【Author】 Wu Dayuan;Wang Jing;Chen Hongji Biochemistry Central Lab., Fujian Medical College, Fuzhou

【机构】 福建医学院生化中心实验室福建医学院寄生虫学教研室福建医学院卫生系

【摘要】 采用荧光分光光度法和紫外分光光度法测定感染伯氏疟原虫(P.b,ANKA株)小鼠血清中维生素A,C,E含量。感染未治组小鼠血清V.A,V.C含量明显低于酮替芬组、酮替芬+氯喹组及正常组,与氯喹组无显著差异,酮替芬及酮替芬+氯喹组的小鼠血清中V.A,V.C含量与正常组无显著差异。各组V.E无显著差异。

【Abstract】 Using fluorecent and visible ultraviolet spectrometries, a comparative study of the V. A, V. E, V. C contents in the sera of mice infected with Plasmidium berghei and treated with ketolfen and chloroquine was made. The results showed that there was no statistically significant difference in V. E content among them (P>0. 05) ,but the V. A and V. C contents were significantly lower in infected mice than in the others (P<0. 01), except the mice treated with chloroquine only(P>0. 05). The V. A and V. C con- tents in infected mice had no obviously difference after treatment with ketolfen and chloroquine and were in the normal level. The relation of V. A and V. C contents in the sera of mice between the infection and treatment with antiplasmodial drug is worthy to be studied further.

【关键词】 酮替芬疟原虫氯喹维生素A维生素C维生素E
【Key words】 ketolfenplasmodiumchlorquinevitamin Avitamin Cvitamin Eserum
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