【摘要】 本文报告1988～1990年,在实施碘盐防治10年后的碘缺乏地区,运用智力测验、脑干听觉诱发电位与临床神经阳性体征检查,垂体-甲状腺轴激素测定和X线骨龄与生长水平等指标,调查7～16岁儿童青少年,发现轻度智力低下者为14.8％,其中54.9％符合亚临床克汀病诊断标准,人群亚克汀病患病率为8.l％。亚克汀病的空间分布与人群碘代谢水平密切相关,它的发生亦循碘缺乏的剂量与作用时间和效应关系,在年龄、性别和民族间的分布上无明显差。经分析,在碘缺乏病控制区的轻度智力低下儿童青少年中,至少有5％可诊断为亚克汀病。并可分为神经损伤型、发育迟滞型和激素性甲低型。更多还原

【Abstract】 In an iodine deficient area of Qinghai Province, where an iodized salt prophylaxis programme had been undertaken for 10 years, 1255 schoolchildren aged 7-16 years were investi gated by IQ, BAEP, TSH level and X-ray bone age. Results showed that 14.8% of the sub-ects had mild mental retartation (MMR) of which 54.9% could be diagnosed as subcretinism while morbidity rate of subcretinism for the whole population was 8.1%. A close relationship between the distribution of subcretinism and iodine metabolism was revealed, and its occurence was subjected to iodine deficiency time-and-dose response while no significant difference was found among ages, sexes and races. Analysis demonstrated that 50% of the schoolchildren with MMR could be diagnosed as subcretinism that could be classified as neurological impairment, delayed development and low thyroid hormone types.更多还原